Touring with and singing in his family band from age four, Luke took up the fiddle at seven. Over the course of the next few years, he won the National Fiddle Contest (in Weiser, Idaho) six times in his respective age categories. His seventh win came in the Grand Champion division at age sixteen, making him the youngest to have earned the title at the time.

Entering Nashvilles Grand Masters fiddle contest at age ten, Luke distinguished himself by being the youngest person to have made the top ten.

Spring of 1999 found Luke moving to Nashville to establish himself as a full time musician. He spent his early years in Tennessee playing fiddle in Ricky Skaggs band, Kentucky Thunder. Following the Skaggs stint, he became a member of the John Cowan Band. More recently Luke has performed with Jim Lauderdale, Darrell Scott, Steve Wariner, Sean Watkins, Sara Watkins, Chris Thile, Glen Phillips and Earl Scruggs, to name a few.

Luke is a perennial instructor at Mark OConnors fiddle camps.

With long-time friend, Casey Driessen, Luke founded the band, Wisechild. The band toured briefly with John Mayer and the Counting Crows.

In addition to violin, Luke plays guitar, sings and writes songs. He is currently working on material for a solo project.

While only one member, Uncle Jerry, was a musician, the entire family had a great taste for music. "I grew up listening to everything from Taj Mahal to Tony Rice, Jean Luc Ponty to the Allman Brothers, Van Morrison and Bob Dylan to Sam Bush and Bela Fleck as well as countless others." Guthrie was eight years old when his father, Joe, promoted the New Grass Revival, featuring Sam Bush, Bela Fleck, John Cowan and Pat Flynn to the Pensacola area. This had a huge impact on young Guthrie. At this same time he started fooling around with the harmonica. Guthrie quickly learned to apply what he learned on harmonica to the guitar.

Around 10 years old Guthrie developed a taste for bluegrass and new acoustic music. He started practicing everyday learning what he could from recordings and the local musicians. At 14, Guthrie joined a well-established bluegrass group, the White Sands Panhandle Band, playing guitar and mandolin. In addition to performing local and regional festivals, the White Sands Panhandle Band also attended SPBGMA (Society for the Preservation of Bluegrass Music in America) Convention in Nashville for several years. It was at these conventions that Guthrie first encountered other stellar performers his age.

At 14, he went to the Telluride Bluegrass Festival and placed third among the adults in the flatpick competition. He won the Alabama guitar and mandolin competitions, two years in a row, at the age of 15 and 16. During this same time, he studied with Pat Flynn (National Guitar Workshop) and Russ Barenberg (Telluride Bluegrass Academy) on guitar and Butch Baldassari on mandolin. At 16, he accompanied lengendary singer, songwriter Tom Paxton and also opened for John McCutcheon with Uncle Jerry.

Guthrie met his next musical adventure in 1995 in Orange Beach, Alabama, the renowned Gove Scrivenor. After sitting in with Gove on a few gigs, Guthrie was asked to join Gove on a regular basis. The duo continued playing together for several years doing local clubs as well as college concerts and opening for such artists as Richie Havens and Al Stewart. Gove and Guthrie also played at the 1996 Sailing Olympics in Savannah, Georgia. In 1997, Gove recorded his "Shine On" album for No Age Records on which Guthrie played mandolin and acoustic guitar. Guthrie was in great company on this recording whose guests included John Prine, Lori White, Nanci Griffith and her band and 'tele master Ray Flacke.

Also in 1997, Guthrie met Nick Branch, an incredible singer/songwriter and guitar player from New York who had recently moved to the Gulf Coast. In addition to playing with Gove, Guthrie took up the guitar and mandolin chair with Nick playing at the notorious roadhouse, the Flora Bama Lounge. It was at this point that Guthrie started playing more electric guitar and forged his entry into swing and jazz styles. Nick and Guthrie played together as a duo for several years before deciding to add a rhythm section. The resulting band quickly became a Gulf Coast favorite and evolved into The Filthy Rich. This band has been Guthrie's main musical endeavor for the past 6 or 7 years. The Filthy Rich has toured Europe as well as headlined festivals and clubs all over the United States. The band has opened for numerous artists including Leon Russell, The Radiators, Marcia Ball, The Sam Bush Band, Chuck Berry and David Alan Coe as well as many others. Guthrie has recorded 4 CDs with Nick and The Filthy Rich as well as performed on radio and TV shows in the U.S. and Europe. (Guthrie has been a featured performer, along with The Filthy Rich and others, on the regionally celebrated Radio Live broadcast since the age of 14.)

Currently, Guthrie is living in Nashville, where he has established himself as a performing and session musician. Guthrie is in demand for playing all styles on guitar and mandolin with remarkable authenticity, feel and taste. Recent performances include; Patty Loveless, Vince Gill, Vassar Clements, Nanci Griffith, Joe Nichols, Jessi Alexander and Kicks Brooks (Brooks & Dunn). Guthrie has also worked with Dave Pomeroy, Kenny Vaughn, Albert Lee, Mark Winchester, Rick Lonow, Dave Roe, Keith Horn, David Ferguson, Bill Vorndick, Roberto Bianco, Cowboy Jack Clement, Ken Fradley, Larry Beader, Horacio El Negro Hernandez, Richard Crooks, Charlie Torez, Greg Brown, Gary Morse, Danny Flowers, Alan Rhody, Shanna Morrison, Emory Gordy Jr., Carl Jackson, Barry Beckett and countless others.

Guthrie joined the Jerry Douglas band in spring 2006. When not on the road with Jerry, you can find him in Nashville playing with the Don Kelley band, an institution of country, swing and blues music. Prior guitarists holding this position include Brent Mason, Redd Volkaert and Johnny Hiland.

Guthrie continues to write, record, perform and instruct on mandolin, acoustic and electric guitars. Guthrie currently endorses GHS strings, Trailer Trash Pedal Boards, Dean Guitars and Aphex Pedals.